Associate Scientist / Scientist: Molecular Engineering, Structure-Function

Company: Adicet Bio, Inc.
Location: Redwood City
Posted on: January 25, 2023

Job Description:

JOIN US! Adicet Bio, Inc. is a clinical stage biotechnology company discovering and developing allogeneic gamma delta T cell therapies for cancer. Adicet is advancing a pipeline of "off-the-shelf" gamma delta T cells, engineered with chimeric antigen receptors (CARs) and adaptors (CAds), to enhance selective tumor targeting and facilitate innate and adaptive anti-tumor immune response for durable activity in patients. For more information, please visit our website at . ASSOCIATE SICENTIST / SCIENTIST: MOLECULAR ENGINEERING, STRUCTURE-FUNCTION Adicet Bio is seeking motivated individuals to advance gamma delta CAR-T development by working at the interface of antibody discovery and cell therapy development. The ideal candidate will be creative, think outside the box, excited to learn, and enjoy working in a collaborative environment that provides huge growth potential. Key responsibilities:

• Work collaboratively with teams across the Research department on new target development projects in immuno-oncology
• Development/optimization/execution of extensive immune cell-based assays for in vitro functional studies, including T cell-based screening of CAR candidates
• Development/optimization/execution of cell-based assays to investigate CAR structure-activity relationships involving engineering and/or functional screening of CAR domains such as hinges and costimulatory domains
• Data generation, data analysis, and communication to immediate team and cross-functional teams Qualifications:
  • BS, MS/MSc or PhD in Biology, Biochemistry, Immunology and related disciplines
  • 3+ years of relevant academic and/or industry experience
  • Broad technical expertise working with antibodies and cell therapies
  • Hands-on tissue culture experience is required (maintaining cell lines, handling primary cells, freezing and thawing cells is required)
  • Experience with cell-based assays such as T cell proliferation, activation, in vitro cytotoxicity assays
  • Hands-on experience with multi-color flow cytometry; experience with phosphoflow is a plus
  • Hands-on experience with fluorescence and luminescence-based readouts using a plate reader
  • Experience with automation of assays to increase throughput is a plus
  • Ability to delve into literature to drive assay development
  • Ability to multitask and meet deadlines in a fast-paced environment
  • Excellent verbal and written communication skills Adicet Bio requires all workers to be fully vaccinated against COVID-19, including the booster dose. At Adicet, our people are our greatest focus. We believe that attracting and retaining the best and brightest is the key to achieving our mission to deliver best-in-class gamma delta T cell therapies for patients fighting cancer. We offer a competitive compensation package including base salary, annual cash bonus, long-term incentives (equity), Employee Stock Purchase Plan (ESPP) and a 401(k) with ROTH and a 4.5% Company match. To ensure the wellness of our employees and their loved ones, we offer comprehensive health plans (medical, dental, vision, etc.), Flexible Health and Commuter Spending Accounts (FSA) and a company matched Health Savings Account (HSA). We also offer a life, AD&D, short and long-term disability insurance, and legal, pet, and various other voluntary insurance programs. We also believe our greatest ideas come when we are refreshed and focused, and we offer generous paid time-off including 12 company holidays with end-of-year shutdown, vacation, sick time, and paid parental leave. Adicet is located in a state-of-the-art facility and works to create an incredible office experience with an onsite gym and various other fitness options, abundant, zero-cost, onsite parking with electric vehicle charging stations and free shuttle (Caltrain), company subsidized lunches (delivered onsite daily) and fully stocked breakrooms. In compliance with California's pay transparency law and in pursuit of pay equity and fairness, we publish salary ranges for all open positions. The pay scale range for this role is $100,000 - $152,000 annualized base salary. The salary of the finalist selected for this role will be set based on a variety of factors, including but not limited to, their qualifications (education, experience, specialty, and training), and peer and market data. This listed salary range represents the Company's good faith and reasonable estimate of the range of possible compensation at the time of posting.

Keywords: Adicet Bio, Inc., Redwood City , Associate Scientist / Scientist: Molecular Engineering, Structure-Function, Engineering , Redwood City, California