Senior Engineer 1 / 2

Company: Adicet Bio, Inc.
Location: Redwood City
Posted on: May 21, 2023

Job Description:

Senior Engineer 1 2 - Careers At Adicet Bio Back To Openings Senior Engineer 1 / 2 Department: Cell Therapy Mfg Ops Location: Redwood City, CA
START YOUR APPLICATION JOIN US! Adicet Bio, Inc. is a clinical stage biotechnology company discovering and developing allogeneic gamma delta T cell therapies for cancer. Adicet is advancing a pipeline of "off-the-shelf" gamma delta T cells, engineered with chimeric antigen receptors (CARs) and adaptors (CAds), to enhance selective tumor targeting and facilitate innate and adaptive anti-tumor immune response for durable activity in patients. For more information, please visit our website at https://www.adicetbio.com . SENIOR ENGINEER 1 / 2 This is a lab-active role in the Manufacturing Sciences and Technology group focusing on the development of the at-scale manufacturing process of Adicet's gamma delta T cell products with opportunities to participate in tech transfer to support cGMP manufacture. Responsibilities:

• Lead and/or execute studies to scale-up CAR T manufacturing processes based on the gamma delta T cell platform using different bioreactor platforms.
• Design and execute cell culture-based experiments utilizing novel technologies to optimize platform processes with closed systems with a focus on scale-up of an allogenic cell therapy.
• Create improvements to platform process for activation, transduction, and expansion unit operations.
• Perform multi-color flow cytometry acquisition and analyses.
• Tracking and ordering requisite consumables for PD and MS&T subteams
• Manage Technology Transfer activities including batch record, SOP, work instruction, and protocol authorship.
• Serve as a subject matter expert and provide technical insights and support in troubleshooting and root cause investigations.
• Manage 1-2 direct reports.
• Accurately compile data in electronic notebook entries and aggregate data files Qualifications:
  • BS/MS/PhD in Biochemical Engineering, Chemical Engineering, Science or Biotechnology.
  • BS with 10+ years or MS with 8+ years' experience in industry setting or PhD with 4+ years of relevant cell therapy experience.
  • A strong background in cell therapy or CAR T products required.
  • Experience with evaluating and developing processes on bioprocess equipment such as Sefia, Rotea, Sepax, LOVO, CliniMACS Prodigy, Xuri, or Sartorius bioreactors.
  • Experience with GMP processing and/or tech transfer related activities
  • Experience in aseptic technique, cell culture, and retroviral or lentiviral transductions
  • Expertise with multi-color flow cytometry for T cells
  • Expertise with Microsoft Office suite, JMP, Prism, FlowJo, Benchling (or other electronic lab notebook software)
  • Conduct and provide help to the team members with analysis and reporting results, and interpretation of data.
  • Possesses good verbal and written communication skills.
  • Ability to operate in a fast paced, industrial environment. At Adicet, our people are our greatest focus. We believe that attracting and retaining the best and brightest is the key to achieving our mission to deliver best-in-class gamma delta T cell therapies for patients fighting cancer. We offer a competitive compensation package including base salary, annual cash bonus, long-term incentives (equity), Employee Stock Purchase Plan (ESPP) and a 401(k) with ROTH and a 4.5% Company match. To ensure the wellness of our employees and their loved ones, we offer comprehensive health plans (medical, dental, vision, etc.), Flexible Health and Commuter Spending Accounts (FSA) and a company matched Health Savings Account (HSA). We also offer a life, AD&D, short and long-term disability insurance, and legal, pet, and various other voluntary insurance programs. We also believe our greatest ideas come when we are refreshed and focused, and we offer generous paid time-off including 12 company holidays with end-of-year shutdown, vacation, sick time, and paid parental leave. Adicet is located in a state-of-the-art facility and works to create an incredible office experience with an onsite gym and various other fitness options, abundant, zero-cost, onsite parking with electric vehicle charging stations and free shuttle (Caltrain), company subsidized lunches (delivered onsite daily) and fully stocked breakrooms. In compliance with California's pay transparency law and in pursuit of pay equity and fairness, we publish salary ranges for all open positions. The pay scale range for this role is $120,000.00 - $166,000.00 annualized base salary. The salary of the finalist selected for this role will be set based on a variety of factors, including but not limited to, their qualifications (education, experience, specialty, and training), and peer and market data. This listed salary range represents the Company's good faith and reasonable estimate of the range of possible compensation at the time of posting. START YOUR APPLICATION

Keywords: Adicet Bio, Inc., Redwood City , Senior Engineer 1 / 2, Engineering , Redwood City, California