Scientist, Immuno-Oncology & Stromal Biomarkers

Company: Bristol Myers Squibb Company
Location: Redwood City
Posted on: January 14, 2023

Job Description:

Working with UsChallenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: When you join BMS, you are joining a diverse, high-achieving team united by a common mission.The Tumor Microenvironment Thematic Research Center (TME TRC) is focused on developing therapeutic targets at the intersection of tumor, stromal and immune biology within the TME with the goal of enhancing responsiveness to checkpoint blockade and targeted therapies and transforming response and durability rates for cancer patients. Comprising of scientists across multiple disciplines we are responsible for the biology and translational science necessary to support drug development from target identification through to first in human studies.Position Summary:The Scientist will join the Immuno-Oncology and Stromal Biomarkers Translational Research team at Bristol Myers Squibb in Redwood City, CA to execute on translational research plans and develop prototype biomarker assays for immune and stromal targets within the tumor microenvironment. The qualified candidate is a highly motivated, interactive, and organized individual that possesses the ability to work across a matrixed environment to support progression of therapeutic targets and is interested in growth as a scientist. This position will specifically support the identification of potential predictive and pharmacodynamic biomarkers for therapeutic programs by characterizing primary human samples and employing them in functional assays. The candidate will also have the opportunity to develop prototype assays for receptor occupancy and target engagement to support clinical development. Finally, the candidate is expected to effectively collaborate with colleagues in the immunology, stroma, oncology, chemistry, and protein engineering groups through clear verbal and written communication skills.Position Responsibilities:In the role as a Scientist within TME TRC Translational Research, Immuno-Oncology & Stromal Biomarkers, the ideal candidate:

• Applies scientific, technical skills, and functional knowledge to independently plan and select appropriate methodologies for translational research studies
• Executes experiments to support indication prioritization and development of predictive and pharmacodynamic biomarker strategies, as well as assay development for therapeutic programs
• Explores combination activity with standard-of-care agents with clinical candidates to support development strategy
• Identifies and potentially develops new technologies and assays relevant for biomarker discovery and analysis
• Documents and reports research findings
• Makes presentations in multidisciplinary meetings, logically presenting information to convey clear, key messages
• Actively participates in internal and external scientific meetings through presentations and critical evaluation of both internal results and emerging scientific literature
• Collaborates effectively across different functions
• May make decisions that impact entire workgroup/project teamExperience = Basic Qualifications:
  • Bachelor's Degree
  • 5+ years of academic and / or industry experience Or
    • Master's Degree
    • 3+ years of academic and / or industry experience Or
      • Ph.D. or equivalent advanced degree in the Life Sciences
      • No experience necessaryPreferred Qualifications:
        • Strong research experience in stromal biology and translational research
        • Strong knowledge of stromal biology, including fibroblast cells, extracellular matrix, and/or vasculature, in the context of cancer biology
        • Independence in experimental execution, data analysis, and troubleshooting
          • Experience in handling primary cells, including cancer associated fibroblasts and immune cells from tumor tissues and peripheral blood
          • Experience performing functional assays, including co-culture assays to model the stromal-immune and cancer cell interactions in tumor tissues
          • Experience with multiple assay/technology platforms such as flow cytometry, ELISA (MSD, Luminex, etc), and genomic analysis (library prep, NanoString, qPCR, etc.)
          • Experience performing DNA, RNA, and protein isolation
          • Strong analytical skills and problem-solving/troubleshooting capabilities
          • Interprets own data, makes conclusions, and recommends next steps
          • Proficiency in utilizing software such as Graph Pad, Microsoft office etc. for data analysis and figure generation
          • Experience with prototype biomarker assay development
          • Some experience in bioinformatics and/or computational biology
          • Attention to detail with impeccable organizational and record keeping skills
          • Excellent interpersonal skills
          • Strong communication skills required, with an ability to communicate and translate ideas and data into concise written and verbal communicationThe starting compensation for this job is a range from $97,000.00 -$135,300.00, plus incentive cash and stock opportunities (based on eligibility). The starting pay takes into account characteristics of the job, such as required skills and where the job is performed. Final, individual compensation is decided based on demonstrated experience. For more on benefits, please visit our BMS Careers site. Eligibility for specific benefits listed in our careers site may vary based on the job and location.BMSONCRDBMSDDTMRCAAround the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to . Visit to access our complete Equal Employment Opportunity statement.BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

Keywords: Bristol Myers Squibb Company, Redwood City , Scientist, Immuno-Oncology & Stromal Biomarkers, Healthcare , Redwood City, California