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Senior Principal Scientist, Oncology Translational Biomarker Lead

Company: Bristol-Myers Squibb
Location: Redwood City
Posted on: May 8, 2024

Job Description:

Working with UsChallenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.The Tumor Microenvironment Thematic Research Center (TME TRC) is focused on developing therapeutic targets at the intersection of tumor, stromal and immune biology within the TME with the goal of enhancing responsiveness to checkpoint blockade and targeted therapies and transforming response and durability rates for cancer patients. Comprising of scientists across multiple disciplines we are responsible for the biology and translational science necessary to support drug development from target identification through to first in human studies.We are seeking a highly motivated and experienced individual with deep translational expertise to join the Translational Development team within the Tumor Microenvironment Thematic Research Center (TME TRC) at Bristol Myers Squibb in Redwood City, CA.Position Responsibilities:In this role as Senior Principal Scientist, Translational Biomarker Lead, within the TME TRC Translational Development team, the ideal candidate:Designs, develops, establishes, and executes well-crafted asset-level oncology translational plans and biomarker strategies for First In Human through Proof of Concept studies within the TME TRC, focused on mechanism of action, target engagement and pharmacodynamic biomarker assays and potential clinical trial patient stratification and selection assays.Accountable for creation and analysis of the assay development and clinical sample analysis plans, budgets, and data, such as generating qualification/validation plans and study reports, developing SOPs, reviewing qualification/validation reports, and contributing to, and reviewing all, pertinent documentation for assigned programs in collaboration with relevant internal subject matter expertsEffectively partners within a highly matrixed organization within the Translational Development group, within the TME TRC, with oncology program colleagues & with external partners to deliver high-quality biomarker data and drive the advancement of therapeutic candidates.Integrates discovery, translational research and other relevant assay information and data, along with logistics and quality considerations, to inform highly complex ideas, activities, and projects.Accountable for providing scientific input and biomarker expertise across all aspects of early development plans and collaborations (such clinical protocols, sample collection tables, sample collection instructions and logistics, scopes of work, data transfer agreements, validation reports, study reports, central lab logistics, posters, publications, investigator brochures, INDs, regulatory documents, etc.)Progresses translational plans into implementation and execution via leading Translational Subteams, monitoring and tracking assay and analysis status and deliverables, via collaboration with internal technical assay execution and/or execution with external contract research organizations (CROs) and/or specialty testing laboratoriesSupports due diligence, collaboration and asset integration activities as neededProactively provides insight into novel ways to incorporate biomarkers into clinical designs to enable early understanding of emerging drug profiles, as well as input around tumor types and potential impact of biomarkers on internal decision making.Provides oversight to progress validated biomarkers into development of diagnostic assays, as neededParticipates in strategic review and input to presentations, publications and internal/ external communications along with accountable program leadership and in governance forumsDevelops solutions and courses of action for senior staff, including identification of risks and risk mitigationsShares expertise, experience, lessons learned and knowledge with translational and other relevant scientific experts and colleagues across the organization Experience =Basic Qualifications:Bachelor's Degree10+ years of academic and / or industry experience -OrMaster's Degree8+ years of academic and / or industry experience -OrPh.D. or equivalent advanced degree in the Life Sciences6+ years of academic and / or industry experience -2+ years of leadership experiencePreferred Qualifications:PhD or MD/PhD with 7+ years of relevant industry experience in the drug development process, preferred within oncology translational biomarker roles and with solid tumor and immune oncology experienceExperience from FIH through at least phase 2 trials, including directly contributing to clinical translational and biomarker components of study protocols, laboratory manuals, investigator brochures, regulatory documents, and INDsExperience interfacing with clinical teams and presenting at strategic meetings, and demonstrated ability to lead and influence others in a highly matrixed work environmentWorking knowledge of all functional areas of drug development, including, biology, toxicology, clinical development, diagnostic development, etcDemonstrated scientific acumen and mechanistic understanding of disease biology and experience in oncology and immuno-oncology drug development (small molecule and biologics)Excellent communication skills and comfortable working in a fast-paced environment where speed is paramountExperience in the design, execution and generation of clinical trial translational biomarker assays and data in oncology across multiple technologies and sample types (e.g. genomics, immunohistochemistry, flow cytometry, immunoassay and other technologies) in various stages of clinical developmentAbility to effectively collaborate with internal and external partners (e.g. CROs, specialty labs, etc.)Comfortable working in a fast-paced environmentThe starting compensation for this job is a range from $159,000.00 - $185,000.00, plus incentive cash and stock opportunities (based on eligibility). -The starting pay rate takes into account characteristics of the job, such as required skills and where the job is performed. -Final, individual compensation will be decided based on demonstrated experience. -Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit our BMS Career Site. -Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick -time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program.BMSONCRDBMSDDTMRCA#LI-HybridIf you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.Uniquely Interesting Work, Life-changing CareersWith a single vision as inspiring as "Transforming patients' lives through science ", every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.On-site ProtocolPhysical presence at the BMS worksite or physical presence in the field is a necessary job function of this role, which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and it enhances the Company culture.BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

Keywords: Bristol-Myers Squibb, Redwood City , Senior Principal Scientist, Oncology Translational Biomarker Lead, Healthcare , Redwood City, California

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