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Sr. Computational Biologist

Company: Synthego Corporation
Location: Redwood City
Posted on: February 22, 2021

Job Description:

Synthego is looking for a Senior Computational Biologist to join our team and help create the world's first fully automated genome engineering factory at scale. This position will own numerous projects and help with the development and deployment of tools and systems to enable industrial-scale molecular biology research, and bring automation to genome engineering.-- As a Senior Computational Biologist at Synthego, you will be contributing to the design and implementation of a comprehensive informatics platform within Synthego Research and Development to better understand genome engineering using CRISPR-based approaches. This role requires a balance of subject-matter expertise, technical depth, and forward-looking vision and creativity.-- What You'll Do

  • Work closely with an interdisciplinary team to develop the next generation of gene editing tools and assays
  • Architect and implement multimodal informatics pipelines, integrating data from sequencing and other modalities to understand and explore new CRISPR technologies
  • Lead a forward-looking vision expanding Synthego's informatics software capabilities, including but not limited to:
  • Pipelines to analyze high dimensional data from transcriptomics and proteomics data sources
  • Tools to explore and understand complex editing outcomes and technologies
  • Write high quality, robust source code with clear documentation About You
    • Hold a PhD in Computational Biology, Bioinformatics, Genomics, Computer Science, or related field with cross disciplinary familiarity of all topics
    • Strong background in transcriptomics (especially RNAseq)
    • Experience and comfort working with large, disparate types of informatics data
    • Experience with bioinformatics standards and conventions, including exposure to public research databases and APIs (NCBI, ClinVar, COSMIC,DepMap)
    • Familiarity with both open source packages and the ability to develop software tools from scratch
    • Strong programming skills, especially applied to data management and analysis
    • Working knowledge and comfort with Python, R, AWS, bash, and SQL
    • Desire to bring original, creative ideas to the continuous improvement of a novel biological factory Nice to Haves
      • 3-5 years of industry or postdoctoral experience
      • Experience with Next Generation Sequencing
      • Familiarity with machine learning systems, especially applied to genomic data
      • Record of project ownership
      • Familiarity with parallelization, containerization and deployment of production software About Us Synthego is a genome engineering company that enables the acceleration of life science research and development in the pursuit of improved human health. The company leverages machine learning, automation, and gene editing to build platforms for science at scale. With its foundations in engineering disciplines, the company's platforms vertically integrate proprietary hardware, software, bioinformatics, chemistries, and molecular biology to advance basic research, target validation, and clinical trials. By providing both commercial and academic researchers and therapeutic developers with unprecedented access to cutting-edge genome engineering, Synthego is at the forefront of innovation, accelerating the development of truly engineered biology.

Keywords: Synthego Corporation, Redwood City , Sr. Computational Biologist, Other , Redwood City, California

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