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Scientist (Protein Biophysical Characterization) mb

Company: Adverum Biotechnologies, Inc.
Location: Redwood City
Posted on: May 3, 2021

Job Description:

Adverum is looking for a Scientist/Senior Scientist to join our team in our Redwood City office. This position reports to Director-level personnel in Assay Development. This person will be working with Assay Development, Quality Control, Process Development, Preclinical, and Clinical teams. This role is responsible for developing, qualifying, transferring, documenting, and troubleshooting product characterization and bioanalytical assays using biophysical technologies.

What you'll do:Participate in the development, qualification, validation, and transfer of quantitative and semi-quantitative biophysical characterization assays to support product release as well as preclinical, and clinical sample bioanalysisEvaluate, implement, and maintain new technology within Assay Development to support product release and sample bioanalysisPresent results, conclusions, and implications to project teams and senior management.Participate in the transfer of processes, technology, and assays to/from internal and external collaborators and outside vendorsMaintain a detailed awareness of industry regulatory guidance and standards for assay validation and performanceMaintain current knowledge of advancing technologies and propose their applications to ongoing projects.Author standard test methods and best-practices documents for the Assay Development groupContribute to development reportsContribute to CMC protocols and regulatory reportsIndependently plan, implement, and complete significant projects with minimal supervision.Serve as SME for biophysical assay technologiesParticipate in scientific meetings and produce original peer-reviewed publicationsMaintain excellent laboratory notebook documentationMentor junior scientistsOther responsibilities may be assigned as neededAbout you:Sr. Scientist level - PhD degree and 8+ years of relevant biotechnology industry experience, Master's degree and 15+ years of relevant biotechnology industry experience, or Bachelor's degree and 20+ years of relevant biotechnology industry experience Scientist level - PhD degree and 2+ years of relevant biotechnology industry experience, Master's degree and 10+ years of relevant biotechnology industry experience, or Bachelor's degree and 15+ years of relevant biotechnology industry experienceExperience working as part of a project teamExperience mentoring a group of lab personnel at various levelsUnderstanding of QC assay requirementsUnderstanding of requirements for pharmacokinetic assaysExtensive experience in assay development, troubleshooting, validation, qualification, and transferWorking knowledge in developing large-molecule and biologics assays in a regulated environment to support some or all of the following: light scattering, AUC, DSF, SPR, LCMS, or other biophysical assay technologies.Experience in enzyme assays and LBA techniques is a plus.Broad knowledge of gene therapy discovery and regulatory guidelines is desiredBackground in the area of AAV characterization a plusPeer-reviewed publications in the area of assay development a plusWorking knowledge of basic statisticsKnowledge of MicroSoft Office Suite. Experience with SoftMax Pro a plus. Experience with GraphPad Prism a plus. Experience with JMP a plus.

Keywords: Adverum Biotechnologies, Inc., Redwood City , Scientist (Protein Biophysical Characterization) mb, Other , Redwood City, California

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