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Senior or Staff Scientist, Tissue Genotyping

Company: Guardant Health
Location: Redwood City
Posted on: May 3, 2021

Job Description:

Senior or Staff Scientist, Tissue Genotyping
Company Description


Guardant Health develops breakthrough diagnostic technologies to improve cancer management. With Guardant360, we offer real-time, biopsy-free tumor sequencing that tracks tumor genomics in real-time and identifies associated treatment options. The assay is used by more than 6,000 oncologists and we partner with more than 50 biopharma companies.

Guardant Health raised over $550M from Sequoia Capital, Khosla Ventures, Lightspeed Ventures, OrbiMed and Softbank, before having a successful IPO on NASDAQ in 2018. Guardant is led by a seasoned management team of thought leaders and successful serial entrepreneurs in next generation sequencing and rare cell diagnostics. They are advised by an oncologist-led medical steering committee from leading cancer centers.

Job Description

To enable Guardant Health to lead the disruption of cancer, a Guardant360 assay development team is seeking a highly motivated, Senior Scientist to develop and validate cutting edge Guardant360 genotyping assays for advanced stage cancers. You will work closely with scientists and process engineers on the team as well as cross-functionally with members from bioinformatics, operations, software, quality, and regulatory affairs. You may be hands on in the lab and will design, implement, and validate novel assays for cancer treatment selection. You will be expected to drive cross-functional projects and meet timelines. The ideal candidate will have strong communication skills, proven track record of NGS assay development, experience with assay validations, and a deep technical understanding of NGS assays and NGS data analysis.

Essential Duties and Responsibilities:
Design, execution, analysis, and documentation of hypothesis driven experiments to develop innovative NGS-based oncology assays Have ownership of assay development deliverables within a cross-functional team including process engineering, operations, bioinformatics, and software. Explore new technologies to drive assay improvements and develop new assays Document product development requirements, development reports, SOPs, and validation results Be highly committed to deliver results in a fast-paced and dynamic start-up organization within Guardant Health Present data, proposals, and progress in various forums and to technical and non-technical audiences Mentor junior members of the team and be committed to helping foster the scientific growth of the team
Deep technical understanding of nucleic acid chemistry and NGS sequencing technologies Strong data analysis skills and extensive experience with NGS data analysis tools such as Python or R Demonstrated success in a fast-paced, dynamic, and result-oriented work environment High attention to detail, with the ability to create clear and concise technical documentation Demonstrated ability to organize and communicate complex information in a clear and concise manner to cross-functional audiences
A highly motivated self-starter and innovative problem solver
Consummate team player: demonstrated ability to contribute in an environment where numerous inputs are required to accomplish complex goals
Preferred Qualifications:
Experience developing DNA or RNA NGS assays from a variety of source material in support of liquid biopsy assay development. Experience with epigenomic assay development including DNA methylation Experience with assay development for automated liquid handling platforms
Staff Scientist : 6+ years experience in development and validation of sequencing-based genomic assays in industry.

Senior Scientist : 3-5years experience in development and validation of sequencing-based genomic assays in industry


Ph.D. in Molecular Biology, Genetics, Biochemistry or related field, or equivalent work experience

Additional Information

Guardant Health is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

Senior or Staff Scientist, Tissue Genotyping

Keywords: Guardant Health, Redwood City , Senior or Staff Scientist, Tissue Genotyping, Other , Redwood City, California

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