Senior Principal Scientist / Associate Director, Translational Flow Cytometry Biomarker
Company: Bristol-Myers Squibb
Location: Redwood City
Posted on: May 3, 2021
Senior Principal Scientist / Associate Director, Translational Flow
Redwood City - CA - US
At Bristol Myers Squibb, we are inspired by a single vision
transforming patients lives through science.In oncology,
hematology, immunology and cardiovascular disease and one of the
most diverse and promising pipelines in the industry each of our
passionate colleagues contribute to innovations that drive
meaningful change. We bring a human touch to every treatment we
pioneer. Join us and make a difference.
The Tumor Microenvironment Thematic Research Center (TME TRC) is
focused on developing therapeutic targets at the intersection of
tumor, stromal and immune biology within the TME with the goal of
enhancing responsiveness to checkpoint blockade and targeted
therapies. Comprising of scientists across multiple disciplines we
are responsible for the biology and translational science necessary
to support drug development from target identification through to
first in human studies.
We are seeking a highly motivated flow cytometry scientist with
significant translational and biomarker background (and preferably
clinical), industry experience to lead the newly formed Flow
Cytometry team. This team is responsible for all flow
cytometry-based biomarker assays from program inception through
First in Human studies, in alignment with clinical development
objectives, as well as clinic-ready target engagement and
pharmacodynamics biomarker assays for TME TRC programs. The data
generated from this team will influence a broad array of decisions
around dose optimization, indication prioritization, and potential
Lead a group (at least 2 direct reports) of scientists to drive the
adaptation, execution, integration and validation of cutting-edge
flow cytometry assays and analysis to develop translational
biomarkers in oncology from preclinical through phase 2 (such as
receptor occupancy, ex vivo assays, immune-profiling etc..)
Serve as a subject matter expert in immunohistochemistry and other
tissue-based assays development and fit-for-purpose validation
Oversee the quality of flow cytometry data generated; provide
subject matter advice to teams in the selection of antibody panels
and panel constituents.
Interact and collaborate with scientists within Translational
Development, Clinical Development, Discovery, Translational
Bioinformatics, and our external business partners (both Academic
and CRO) to integrate flow-based biomarker data into an overall
understanding of drug MOA and efficacy.
Responsible for developing partnerships in a matrix environment,
influencing project strategies, and providing expertise in
technology development and implementation.
Must be able to set and understand priorities in a local and
matrixed environment, must be a team player with a collaborative
spirit, and capable of building and maintaining networks within and
outside the organization.
PhD in a scientific field (Immunology, Oncology, Biology or
similar) at least 8+ years of experience in industry, contract
research organization, or pharma setting
Must be an expert in flow cytometry assay design, development,
trouble shooting,validation and implementation on a broad array of
Demonstrate expertise with complex flow cytometry and its data is a
must with the use of commercial flow cytometry software including
BD FACS Diva, FlowJo, FCS Express, Cytobank, ViSNE, TiSNE, etc.
Hands-on experience with the BD LSRFortessa, BD Symphony, Cytek
Significant experience managing a diverse team in high pressure
Ability to clearly communicateand operate in a highly matrixed
Proven track record of handling multiple high priority tasks in
parallel with internal and external collaborators
Demonstrated history of developing careers of others
Demonstrated ability to work effectively in highly matrixed
Outstanding communication skills and ability to influence strategic
directions of organizations
History of scientific accomplishments
CRO experience, knowledge of CLIA/GCLP practices is a plus, but not
Around the world, we are passionate about making an impact on the
lives of patients with serious diseases. Empowered to apply our
individual talents and diverse perspectives in an inclusive
culture, our shared values of passion, innovation, urgency,
accountability, inclusion and integrity bring out the highest
potential of each of our colleagues.
Bristol Myers Squibb recognizes the importance of balance and
flexibility in our work environment. We offer a wide variety of
competitive benefits, services and programs that provide our
employees with the resources to pursue their goals, both at work
and in their personal lives.
W ere creatinginnovative medicines for patients fighting serious
diseases. Were also nurturing our own diverse team with inspiring
work and challenging career options. No matter the role, each one
of us makes a contribution. And that makes all the difference.
Keywords: Bristol-Myers Squibb, Redwood City , Senior Principal Scientist / Associate Director, Translational Flow Cytometry Biomarker, Other , Redwood City, California
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