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Senior Principal Scientist / Associate Director, Translational Flow Cytometry Biomarker

Company: Bristol-Myers Squibb
Location: Redwood City
Posted on: May 3, 2021

Job Description:



Senior Principal Scientist / Associate Director, Translational Flow Cytometry Biomarker

Redwood City - CA - US

At Bristol Myers Squibb, we are inspired by a single vision transforming patients lives through science.In oncology, hematology, immunology and cardiovascular disease and one of the most diverse and promising pipelines in the industry each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

The Tumor Microenvironment Thematic Research Center (TME TRC) is focused on developing therapeutic targets at the intersection of tumor, stromal and immune biology within the TME with the goal of enhancing responsiveness to checkpoint blockade and targeted therapies. Comprising of scientists across multiple disciplines we are responsible for the biology and translational science necessary to support drug development from target identification through to first in human studies.

Position Summary:

We are seeking a highly motivated flow cytometry scientist with significant translational and biomarker background (and preferably clinical), industry experience to lead the newly formed Flow Cytometry team. This team is responsible for all flow cytometry-based biomarker assays from program inception through First in Human studies, in alignment with clinical development objectives, as well as clinic-ready target engagement and pharmacodynamics biomarker assays for TME TRC programs. The data generated from this team will influence a broad array of decisions around dose optimization, indication prioritization, and potential drug combinations.

Responsibilities:

Lead a group (at least 2 direct reports) of scientists to drive the adaptation, execution, integration and validation of cutting-edge flow cytometry assays and analysis to develop translational biomarkers in oncology from preclinical through phase 2 (such as receptor occupancy, ex vivo assays, immune-profiling etc..)

Serve as a subject matter expert in immunohistochemistry and other tissue-based assays development and fit-for-purpose validation

Oversee the quality of flow cytometry data generated; provide subject matter advice to teams in the selection of antibody panels and panel constituents.

Interact and collaborate with scientists within Translational Development, Clinical Development, Discovery, Translational Bioinformatics, and our external business partners (both Academic and CRO) to integrate flow-based biomarker data into an overall understanding of drug MOA and efficacy.

Responsible for developing partnerships in a matrix environment, influencing project strategies, and providing expertise in technology development and implementation.

Must be able to set and understand priorities in a local and matrixed environment, must be a team player with a collaborative spirit, and capable of building and maintaining networks within and outside the organization.

Qualifications:

PhD in a scientific field (Immunology, Oncology, Biology or similar) at least 8+ years of experience in industry, contract research organization, or pharma setting

Must be an expert in flow cytometry assay design, development, trouble shooting,validation and implementation on a broad array of platforms

Demonstrate expertise with complex flow cytometry and its data is a must with the use of commercial flow cytometry software including BD FACS Diva, FlowJo, FCS Express, Cytobank, ViSNE, TiSNE, etc.

Hands-on experience with the BD LSRFortessa, BD Symphony, Cytek Aurora

Significant experience managing a diverse team in high pressure situations

Ability to clearly communicateand operate in a highly matrixed environment

Proven track record of handling multiple high priority tasks in parallel with internal and external collaborators

Demonstrated history of developing careers of others

Demonstrated ability to work effectively in highly matrixed environment

Outstanding communication skills and ability to influence strategic directions of organizations

History of scientific accomplishments

CRO experience, knowledge of CLIA/GCLP practices is a plus, but not a must

BMSONCRD, BMSDDTMRCA

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

W ere creatinginnovative medicines for patients fighting serious diseases. Were also nurturing our own diverse team with inspiring work and challenging career options. No matter the role, each one of us makes a contribution. And that makes all the difference.

Keywords: Bristol-Myers Squibb, Redwood City , Senior Principal Scientist / Associate Director, Translational Flow Cytometry Biomarker, Other , Redwood City, California

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