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Postdoctoral Research Fellow - Molecular and Cellular Cancer Biologist

Company: Revolution Medicines, Inc.
Location: Redwood City
Posted on: May 3, 2021

Job Description:

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit high-value frontier targets in RAS-addicted cancers. The company's R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Project:

  • To be designed by the research fellow, in collaboration with RevMed scientists, focusing on cellular mechanisms underlying sensitivity and resistance to RAS(ON) inhibitors.

  • Topics of interest include:
  • Role of RAS effectors other than RAF kinase in RAS-driven transformation.

  • RAS-independent mechanisms of ERK activation.

  • Unique properties of specific RAS mutations that drive sensitivity and resistance to RAS(ON) inhibitors.

  • Mechanisms of adaptive resistance to RAS(ON) inhibitors in preclinical models.

  • The research fellow will have access to extensive screening, sequencing, and "-omic" datasets, as well as RAS(ON) and RAS companion inhibitor tool compounds in order to support the project.

  • Project will be focused primarily on in vitro mechanistic biology, with some in vivo investigation possible in collaboration with the Cancer Pharmacology group.

The Opportunity:

  • Join a team of motivated scientists in a fast-paced environment focused on the discovery and development of novel medicines for frontier cancer targets.

  • Access to top capabilities, equipment, expertise and knowledge across chemistry, structural biology, cancer biology, drug metabolism and pharmacology.

  • You will be expected to present your research at internal and external meetings and will also have the opportunity to interact within the greater scientific community, including inviting and hosting outside speakers of your choice.

  • Timely publication of innovative science in high-impact journals is expected along with applicable patent filings.

  • Immersion in our high energy start-up environment will provide valuable exposure to world class drug discovery expertise and position you for career opportunities in pharma, biotechnology, and academia.

Required Experience, Skills, and Education:

  • Ph.D. cell biology, biochemistry, or related discipline.

  • Strong track record of research productivity and technical innovation as evidenced by high-quality, impactful publications.

  • Ability to design cell-based experiments using genetic and pharmacological manipulation of proteins and pathways in relevant cell systems.

  • Experience analyzing large genomic or proteomic data sets helpful but not essential.

  • Ability to thrive in a multi-discipline team environment is essential.

  • Rigorous, quantitative and detail-oriented experimentalist with excellent written and verbal communication skills.

Keywords: Revolution Medicines, Inc., Redwood City , Postdoctoral Research Fellow - Molecular and Cellular Cancer Biologist, Other , Redwood City, California

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