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Senior Scientist, Reagent Development (Tissue Genotyping)

Company: Guardant Health, Inc.
Location: Redwood City
Posted on: May 3, 2021

Job Description:

Guardant Health is a leading precision oncology company focused on helping conquer cancer globally through use of its proprietary blood tests, vast data sets and advanced analytics. The Guardant Health Oncology Platform leverages capabilities to drive commercial adoption, improve patient clinical outcomes and lower healthcare costs across all stages of the cancer care continuum. Guardant Health has launched liquid biopsy-based Guardant360, Guardant360 CDx and GuardantOMNI tests for advanced stage cancer patients. These tests fuel development of its LUNAR program, which aims to address the needs of early stage cancer patients with neoadjuvant and adjuvant treatment selection, cancer survivors with surveillance, asymptomatic individuals eligible for cancer screening and individuals at a higher risk for developing cancer with early detection.

To enable Guardant Health to lead the disruption of cancer treatments through non-invasive cancer screening, the Technology Development Team is seeking a highly motivated Senior Scientist to develop, test, and improve existing and new technologies for rare variant studies with next-generation sequencing. At Guardant, we leverage the most advanced technologies and work with leaders in many different fields to create the most impactful and meaningful technologies for cancer management.

As a Senior Scientist supporting product and technology development, you will work with members within the team and interface with multiple teams including process engineering, clinical operations, bioinformatics, quality control and regulatory affairs. You will be hands-on in the lab and be involved in the design, implementation and validation of new technologies related to liquid biopsy sequencing assays for the detection, treatment, and monitoring of all cancer types.

Essential Duties and Responsibilities:

  • Work in a team environment and independently to develop, test, and improve sample isolation and preparation technologies for rare variant studies with next-generation sequencing
  • Think creatively and apply knowledge to design experiments and analyze data for NGS applications in oncology diagnostics
  • Be highly committed and deliver results in a fast-paced start-up environment
  • Transfer new technologies into production environments, write supporting documentation including experiment protocols and reports, SOPs, Specifications, and change requests
  • Design and perform experiments to develop and improve our assay workstreams
  • Lead in troubleshooting efforts with our Tech Dev team and among other teams and capture lessons learned
  • Engage in technologies from early design of products to support after they are transferred
  • Present data, proposals, and progress in various forums to technical and non-technical audiences
  • Strong foundation in molecular biology techniques and NGS assay development, exemplified by publications, patent applications, or previous product development experience
  • Comprehensive knowledge of nucleic acid sample isolation, preparation, and NGS sequencing technologies
  • Data analysis skills with experience in bioinformatics and in handling large datasets
  • Experience with liquid handling platforms is a plus
  • Experience with product development in a regulated environment is a plus
  • Consummate team player: demonstrated ability to contribute to an environment where numerous contributions are required to accomplish complex goals.
  • Excellent interdisciplinary communication skills required
  • Enjoy working independently and collaboratively in a fast-paced environment and able to adapt to change
  • Highly motivated and responsible self-starter and independent problem solver
  • Self-driven and curious


  • BA/BS with 15+ years of industry experience; MA/MS with 10+ years of industry experience; PhD with 8+ years of post-PhD experience in Molecular Biology, Genetics, Biochemistry, or related field
  • 3+ years of industry work experience preferred

Employee may be required to lift routine office supplies and use office equipment. Majority of the work is performed in a desk/office environment; however, there may be exposure to high noise levels, fumes, and biohazard material in the laboratory environment. Ability to sit for extended periods of time.

Guardant Health is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

All your information will be kept confidential according to EEO guidelines.

To learn more about the information collected when you apply for a position at Guardant Health, Inc. and how it is used, please review our Privacy Notice for Job Applicants.


Keywords: Guardant Health, Inc., Redwood City , Senior Scientist, Reagent Development (Tissue Genotyping), Other , Redwood City, California

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