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Scientist (II or III), Molecular & Cellular Engineering (BioTx)

Company: Codexis
Location: Redwood City
Posted on: May 3, 2021

Job Description:

Are you ready to join our mission to fight rare diseases?  Do you have a passion to help people have better quality of life?   Come be part of the Codexis, Inc. team where every day we get to unlock the power of proteins!

Codexiss Biotherapeutics division uses our world-leading CodeEvolver protein engineering platform to discover novel therapies for the treatment of genetic disorders and other debilitating disease.  We engineer proteins with high efficacy and safety with the goal of delivering the therapeutic to patients as an enzyme replacement, mRNA, or gene therapy.

But we cant do it without YOU!

We are rapidly growing and we are presently seeking to expand or pipeline and diversify applications of our technology platform. To help us meet our goals, we are looking to hire a Scientist to join our Molecular and Cellular Engineering Team. 

If any of the below describes you, we would love to meet you!

  • Passionate about large-molecule drug discovery to improve the quality of life for patients with rare diseases.
  • Experienced or interested in novel technologies for protein engineering and directed evolution.
  • Excited about the ability to apply your knowledge to development of novel methods and workflows

In this role you will be responsible for:

  • Design and construction of gene libraries and expression vectors.
  • Design and construction of fusion constructs.
  • Characterization of gene variants.
  • Cloning of genes and genetic pathways.
  • Optimization of recombinant protein expression in multiple expression hosts.
  • Development and optimization of cell-based assays.
  • Providing technical guidance for protein engineering projects.
  • Analysis and interpretation of DNA sequencing data and assay data. Analysis and interpretation of contribution of mutations to desired properties of gene variants.
  • Working independently and with project teams to provide support and assistance to all phases of directed evolution projects, contribute to team presentations and written reports.
  • Maintain a safe and efficient work place, follow safe lab practices and organize lab environment.

To be successful in this role, your background and experience should include:

  • PhD in Molecular Biology or related field with 3+ years of industry experience
  • Experience with designing constructs for protein expression in mammalian hosts.
  • Experience with cell-based assays or display assays (yeast or phage display); knowledge and understanding of directed evolution preferred.
  • Experience with DNA manipulation, library design and generation, protein expression and multiple expression hosts.
  • Ability to independently develop, validate and troubleshoot protocols.
  • Ability to prioritize responsibilities and multi-task.
  • Ability to provide technical vision, leadership and guidance to project teams.
  • Ability to think critically, work both independently and within cross- disciplinary project teams.
  • Must be able to work and communicate well within project teams.
  • Must be motivated and able to work under tight deadlines.
  • Motivated and able to work under tight timelines, flexible, able to work and communicate well within project teams.
  • Excellent communications skills, both oral and written, presentation skills and interpersonal skills.

What can Codexis offer you? (besides an amazing and collaborative culture?)

  • Full benefits your first day
  • 100% match on 401k
  • Generous flex time off
  • Fitness reimbursement
  • Free fitness classes
  • Back up child/dependent care
  • Commuter vouchers
  • Much more!


Codexis is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status.

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Keywords: Codexis, Redwood City , Scientist (II or III), Molecular & Cellular Engineering (BioTx), Other , Redwood City, California

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