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Senior or Staff Scientist, Sustaining & Process Improvement Lead (LUNAR)

Company: Guardant Health
Location: Redwood City
Posted on: May 3, 2021

Job Description:

Senior or Staff Scientist, Sustaining & Process Improvement Lead (LUNAR)
Company Description

Guardant Healthis a leading precision oncology company focused on helping conquer cancer globally through use of its proprietary blood tests, vast data sets and advanced analytics.The Guardant Health Oncology Platform is designed to leverage our capabilities in technology, clinical development, regulatory and reimbursement to drive commercial adoption, improve patient clinical outcomes and lower healthcare costs.In pursuit of our goal to manage cancer across all stages of the disease,Guardant Healthhas launched two liquid biopsy-based tests, Guardant360 and GuardantOMNI, for advanced stage cancer patients, and is developing programs for recurrence and early detection, called Project LUNAR. Since its launch in 2014, Guardant360 has been used by more than 5,000 oncologists, over 40 biopharmaceutical companies and all 27 of the National Comprehensive Cancer Network centers.

Job Description

To enable Guardant Health to lead the disruption of cancer treatments through non-invasive cancer screening, the Minimal Residual Disease (MRD) program is seeking a highly motivated Senior Scientist to lead the groups sustain/support team in the improvement and validation of novel technologies intended to revolutionize early-detection of residual disease via next-generation sequencing in a regulated environment. At Guardant, we leverage the most advanced technologies and work with leaders in many different fields to create the most impactful and meaningful technologies for cancer management.

As a Senior Scientist in the MRD technology organization, you will interface with multiple teams including process engineering, clinical operations, research operations, and bioinformatics. You will be hands on in the lab and be required to design, improve, implement, and validate new technologies related to liquid biopsy sequencing assays for the early detection, treatment, and monitoring of all cancer types. You will play a critical role in developing the standards and metrics by which assay performance is monitored and maintained, and be responsible for developing a support team of more junior scientists and research associates to develop existing assays as well as future product offerings.

Guardant's MRD program seeks to leverage our leadership in the field of liquid biopsy to address a core unmet need in clinical cancer care. It's success is being driven by a team of highly-motivated experts such as yourself, passionate about the potential to revolutionize the field of cancer diagnosis and management thus saving patient lives.

Essential Duties and Responsibilities:
Be able to work in a team environment and independently to develop, test and validate technologies with next-generation sequencing in both CLIA/CAP and FDA-regulated environments. Think creatively and apply knowledge to design validation experiments and analyze data for NGS applications in oncology diagnostics Document product development requirements and validation results in the form of professional quality reports following Good Documentation Practices. Be highly committed and deliver results in a fast-paced start-up environment

3-5 years of industry experience in genomics or molecular biology, preferably developing diagnostic tests.

Comprehensive knowledge of sample preparation and sequencing technologies

Experience in development or optimization of nucleic acid technologies with a strong preference related to sequencing-based genomic assays, preferably in regulated environments.

Deep technical knowledge of NGS library preparation, target enrichment, and rigorous product development practices

Familiarity with commonly used bioinformatics tools in the analysis of NGS data

Excellent interdisciplinary communication skills required

Good organization skills, and detailed orientated

Self-driven and strong team player with proven track record


PhD in Biology, Molecular Biology, Biochemistry, or similar fields.

Additional Information

All your information will be kept confidential according to EEO guidelines.

Employee may be required to lift routine office supplies and use office equipment. Majority of the work is performed in a desk/office environment; however, there may be exposure to high noise levels, fumes, and biohazard material in the laboratory environment. Ability to sit for extended periods of time.

Senior or Staff Scientist, Sustaining & Process Improvement Lead (LUNAR)

Keywords: Guardant Health, Redwood City , Senior or Staff Scientist, Sustaining & Process Improvement Lead (LUNAR), Other , Redwood City, California

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