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Scientist I/II, AAV Analytics

Company: Codexis
Location: Redwood City
Posted on: June 2, 2021

Job Description:

 

 

Are you ready to join our mission to fight rare diseases?  Do you have a passion for helping people have a better quality of life? Come be part of the Codexis, Inc. team where every day we get to unlock the power of proteins!

Codexiss Biotherapeutics division uses our world-leading CodeEvolver protein engineering platform to discover novel therapies for the treatment of genetic disorders and other debilitating disease. We engineer proteins with high efficacy and safety with the goal of delivering the therapeutic to patients as an enzyme replacement, mRNA, or gene therapy.

But we cant do it without YOU!

To help us meet our goals, we are looking to hire a Scientist, AAV Analytics. In this position, the successful candidate will be a key member of our Vector Sciences group responsible for establishing assays and characterizing AAV vectors for Codexis gene therapy programs and contributing to the design of Codexis engineering platforms. The ideal candidate will have broad expertise with AAV production, as well as experience designing and generating viral vectors capsids to deliver genetic payloads. Strong organizational skills, the ability to tackle multiple projects simultaneously and a desire to work in a fast-paced and collaborative environment are essential.
 

If any of the following describe you, we would love to meet you!

  • Passionate about AAV Gene Therapy to improve the quality of life for patients with rare diseases.
  • Ready to apply your technical skills to build and lead a small team of researchers vector and protein sciences group
  • Eager to apply your AAV characterization and analytics technical skills to support preclinical research for AAV Gene Therapy programs

In this role your day will be filled doing the following:

  • Develop and execute assays to assess the quality of research vectors, including characterization and release assays for translational studies.
  • Support Gene Therapy projects by processing and analyzing biodistribution of vectors.
  • Direct assay qualification studies, write study protocols, and report findings
  • Develop vector lot release testing strategy and sampling plans, and review all testing documents and data in preparation of vector release (COA)
  • Design and implement efficient systems to monitor/ maintain vector and sample inventory

To be successful in this role, your background and experience should include:

  • PhD in a life sciences or engineering discipline with 3+ years of post-degree experience in an academic or industry laboratory setting, or BS/MS with 6+ years of experience
  • Familiarity with standard analytical techniques for characterizing rAAV Vectors (SEC, AUC, Purity, CE, RP-HPLC, DLS, Potency)
  • Prior experience training, mentoring, or supervising research associates desired.
  • Highly organized, attentive to detail, and able to work under tight timelines in a collaborative team setting.
  • Excellent interpersonal and communication skills.

The skills and experience you will use regularly will be:

  • AAV production and purification in HEK and/or Baculo Sf9 cells
  • Restriction enzyme cloning, Gibson Assembly, Golden Gate Assembly
  • qPCR/ddPCR principles and analysis
  • Mammalian cell culture and good aseptic technique
  • Data analysis software including Excel, Prism, Snapgene (or similar), etc.
  • DNA/RNA sequencing and analysis
  • Ability to troubleshoot and think analytically
  • Strong work ethic and a collaborative, team player
  • Strong attention to detail
  • Ability to multitask and support multiple projects simultaneously
  • Effective communication

What can Codexis offer you? (besides an amazing and collaborative culture?)

  • Full benefits on your first day
  • 100% match on 401k (up to 4%)
  • Generous flex time off
  • Fitness reimbursement
  • Free fitness classes
  • Back up child/dependent care
  • Commuter vouchers
  • Much more!

 

PRINCIPALS ONLY
NO AGENCIES OR THIRD PARTIES

Codexis is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status.

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Keywords: Codexis, Redwood City , Scientist I/II, AAV Analytics, Other , Redwood City, California

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