Systems Engineer

Company: Guardant Health, Inc.
Location: Redwood City
Posted on: June 2, 2021

Job Description:

Guardant Health is a leading precision oncology company focused on helping conquer cancer globally through use of its proprietary blood tests, vast data sets and advanced analytics. The Guardant Health Oncology Platform leverages capabilities to drive commercial adoption, improve patient clinical outcomes and lower healthcare costs across all stages of the cancer care continuum. Guardant Health has launched liquid biopsy-based Guardant360, Guardant360 CDx and GuardantOMNI tests for advanced stage cancer patients.

At Guardant Health, we leverage the most advanced technologies and work with leaders in many different fields to create the most impactful and meaningful technologies for cancer management.

To enable Guardant Health to continue to lead the disruption of cancer treatments through non-invasive cancer screening, the Technology Development Engineering team is seeking a highly motivated Engineer to lead the execution of sustaining and troubleshooting activities pertaining to our launched assays for rare variant studies with next-generation sequencing.

The ideal candidate will have prior, demonstrated experience designing, developing, testing, implementing, and supporting automated sample-processing workflows using a requirements-driven approach in a clinical laboratory or other molecular biology-based laboratory settings. Will leverage an understanding of molecular biology and biochemistry to troubleshoot analytical and preparative processes. The successful candidate will apply scientific methods and engineering skills to improve Guardant Health's sample processing workflows' scalability.

Duties and Responsibilities:

* Design and improve processes to continually improve legacy assay/reagent manufacturing workstreams. * Collaborate cross-functionally with operations, assay, and bioinformatics to facilitate effective delivery of sustaining and support deliverables. * Demonstrate a solid understanding of business and user requirements to improve efficiency, throughput, and quality of processes. * Conceptualize and perform feasibility studies on new assay improvements for automation, equipment, and processes. * Ensure Lab Operations needs are met through end-to-end system partnership for long term sustainability and efficiency. * Write experiment reports and update SOPs as needed. * Lead in troubleshooting efforts with our Operations teams and capture lessons learned. * Ensure all work is performed and documented in compliance with applicable regulatory and quality practices (FDA, ISO13485, CAP/CLIA). * Present data, proposals, and progress in various forums to technical and non-technical audiences. * Knowledge of and work experience with FDA regulated products. * Knowledge of quality system use for the creation and continued compliance of products. * Be a mentor to junior team members. * BS degree in engineering or science, with 5-8 years of related experience, MS with 4+ years of related work experience, or a Ph.D. with 3+ years of related work experience. Preferred degrees: Molecular Biology, Genetics or Biochemistry, Bio-Engineering or, Chemical Engineering. * Proven capability streamlining workflows and automated laboratory processes, and instrumentation systems, from concept generation. * Experience designing and performing process validation and implementation. * Hands-on experience with operating and programming liquid handling robotics platforms (e.g., Hamilton Star, Hamilton Vantage, Agilent Bravo, Tecan) * Demonstrated ability to organize, document, and communicate scientific data. * Proficient at statistically analyzing data, monitoring data quality, and troubleshooting technical problems. * Consummate team player: demonstrated ability to contribute to an environment where numerous contributions are required to accomplish complex goals. * Must be able to work independently and collaboratively in a fast-paced environment and able to adapt to change. * Highly motivated, inquisitive, and a responsible self-starter and independent problem solver. * Support troubleshooting activities within the clinical lab with support for ongoing technologies after they are transferred. * Strong communication and interpersonal skills. * Ability to work internally and externally with diverse scientific, engineering, operational, and regulatory individuals. * Experience working within regulated environments (IVD, LDT, etc.). * Has NGS or Diagnostic company background.

Preferred Skills:

* 3+ years of direct industry work experience * Product development in a regulated environment. * Experience with assay development for automated liquid handling platforms . * Experience in sustaining development or support.

Work Environment:

Employee may be required to lift routine office supplies and use office equipment. Majority of the work is performed in a desk/office environment; however, there may be exposure to high noise levels, fumes, and biohazard material in the laboratory environment. Ability to sit for extended periods of time.

All your information will be kept confidential according to EEO guidelines.

Keywords: Guardant Health, Inc., Redwood City , Systems Engineer, Other , Redwood City, California