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Mass Spectrometry and Data Analysis Scientist

Company: Bristol Myers Squibb
Location: Redwood City
Posted on: June 6, 2021

Job Description:

At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science. In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science. In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

The Discovery Biotherapeutics team at BMS seeks to understand the structure and function of complex molecules such as antibodies and endogenous proteins in order to optimize their utility as therapeutic agents. We collaborate with biology and translational scientists imbedded in the Thematic Research Centers in order to prosecute Targets and Biological pathways with disease modifying potential. By using a blend of internal and external technologies and capabilities, we work to discover and deliver first-in-class as well as best-in-class molecules that warrant clinical evaluation for patient benefit.

Position Summary

We are seeking a skilled and enthusiastic Scientist to join our Protein Analytics Group. Your primary responsibilities will be to characterize the primary, tertiary, and quaternary protein structure using a variety of characterization techniques such as mass spectrometry, liquid chromatography, and other analytical techniques. You will also analyze complex mass spectroscopic data sets derived from chemical foot printing, post-translational modification, de novo sequencing and proteomic experiments. The successful candidate will represent the group at discovery team meetings for a variety of oncology projects, where you contribute with your protein characterization and mass spectroscopic expertise to the selection and optimization of our therapeutic antibodies.

Responsibilities

  • Characterize protein-protein interactions and binding interfaces through epitope mapping and crosslinking studies.
  • Design and execute mass spectrometry-based proteomics studies.
  • Develop and run multiple types of protein characterization assays such as LC-MS, SEC-MALS, glycan analysis, amino acid concentration, etc.
  • Perform structural characterization of antibody and protein therapeutics to support lead candidate selection.
  • Develop workflows to analyze and visualize complex proteomics datasets.
  • Present data and analysis in written and oral form to project leaders and teams
  • Collaborate closely with Biology, Hybridoma and Protein Engineering groups

Requirements

  • PhD with 2 - 5 years, Masters with 7+ years industrial and/or relevant experience in Chemistry, Biochemistry, Biophysics, or a related field
  • Expertise in characterizing protein structure including molecular weight, aggregation state, glycan structure, post-translational modifications, etc.
  • Expertise with protein and peptide mass spectrometry
  • Highly experienced candidate with programming skills and experience developing computational algorithms and software for proteomics data processing and visualization
  • Proficient with mass spectrometry data analysis pipelines database search algorithms for proteomics
  • Experience with SEC, HILIC, RP chromatography
  • Strong attention to detail and excellent bench skills a must
  • Excellent written and oral communication skills
  • Excellent time management and organizational skills
  • Ability to contribute to multidisciplinary discovery teams

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application, or any part of the recruitment process direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

Keywords: Bristol Myers Squibb, Redwood City , Mass Spectrometry and Data Analysis Scientist, Other , Redwood City, California

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