Senior Bioinformatics Scientist, Assay Development Analytics

Company: Karius
Location: Redwood City
Posted on: January 9, 2022

Job Description:

About KariusKarius is a venture-backed life science startup focused on transforming the way infectious diseases are diagnosed. Combining Next-Generation Sequencing and proprietary data analysis, we can identify over 1,000 pathogens from a single blood sample with typical turnaround time in one business day. By unlocking the information present in microbial cell-free DNA, we're helping doctors quickly solve their most challenging cases, with a future vision of accelerating clinical trials, discovering new microbes, and reducing patient suffering worldwide.Why Should You Join Us?Karius core mission is to conquer infectious diseases through innovations around genomic sequencing and machine learning. The company's platform is already delivering unprecedented insight into the microbial landscape, providing clinicians with a comprehensive test capable of identifying more than a thousand pathogens directly from blood. Through this journey, we realized that the microbial cell-free DNA platform may hold value that goes well beyond the direct diagnosis of infections. You, as part of the Karius team, will be able to see the immense opportunity to expand the human knowledge around this emerging topic and apply it directly to critical problems in human health and disease.Position Summary You are highly curious and creative and desire to continuously grow and improve in your goal to make an impact on patients. You will be a key member of the Assay Development Analytics (ADA) team that helps drive the computational aspects of assay development, focusing on analysis and optimization of new chemistries and lab techniques. You will participate in experimental design, conduct thoughtful computational analyses by determining the analysis plan and executing it using the necessary tools and methodologies. You will work closely with colleagues in Molecular Biology to understand and deliver on our shared goals. You are a self-starter and always like to find ways to make things better.Reports to: Director, Assay Development AnalyticsLocation: Redwood City, CAPrimary Responsibilities--- Individual contributor to Assay Development Analytics (ADA), which drives the computational aspects of assay development, focusing on analysis and optimization of new chemistries and lab techniques. --- Participate in experimental design, conduct computational analyses, understand rationale, set the analysis plan, and execute using the necessary tools and methodologies to deliver innovative assays.--- Work closely with colleagues in Molecular Biology to understand the properties of the assays and ways to improve our technologies.--- Continue to grow and learn in the necessary mathematical, technological, and software aspects of the field through internal knowledge acquisition and staying current with the latest relevant literature.--- Open to exploring multiple approaches for problem-solving and modeling including borrowing across a wide range of quantitative disciplines.--- Share a passion for ensuring the quality of our statistical analysis, via reliability, reproducibility, and rigor.What's Fun About the Job?Karius is operating at the edge of what is now known to be possible in infectious disease diagnostics. With that, comes a wave of new and incredible challenges and opportunities. To deliver on that value, you will be tapping into some of the most advanced technologies, architecting and innovating where the current solutions simply don't suffice. You will get to see how much your work really matters. -Travel: No travel required.Physical RequirementsSubject to extended periods of sitting and/or standing, vision to monitor, and moderate noise levels. Work is performed in an office environment.Position Requirements--- Ph.D. in computer science, statistics, mathematics, physics, chemistry, or related fields, preferably -with a focus on computational biology.--- 2+ years of biotech, pharma, or relevant experience, or equivalent; title will be commensurate with experience.--- Publications of investigation and interpretation of biological data.--- Experience with, and understanding of, modern statistics and machine learning.--- Proficiency in working with high dimensional, large-scale datasets with low signal-to-noise.--- Excellence at communication and collaboration within a cross-functional team.--- Self-starting mentality and ability to drive results.--- Post-doc experience -in genetics, statistics, chemistry, or related fields.--- Relevant publications.--- Innovation surrounding molecular biology.--- Familiarity with a range of relevant laboratory techniques (either through hands-on work or from collaborations with laboratory-focused colleagues).--- Familiarity and experience with bioinformatics tools, approaches, and workflows, particularly those related to next-generation sequencing data analysis.--- Familiarity with design of experiments (DOE) approaches to optimize process settings.Personal Qualifications--- Passionate, purpose-driven, and excited about Karius' mission.--- Excellence at communication and collaboration within a cross-functional team.--- Detail oriented with exceptional organizational and time management skills.--- Self-starting mentality and ability to drive results.--- Comfortable working in an environment which combines both research aspects as well as development.--- Ability to work effectively and efficiently in a fast-paced (startup) environment. At Karius, we value a diverse and inclusive workplace and provide equal employment opportunity for all applicants and employees, and are committed to honor and invest in the full diversity of people, in our hiring, recruiting, and development of employees across the Company. All qualified applicants for employment are encouraged to apply and will be considered without regard to an individual's race, color, sex, gender identity, and gender expression (including transgender individuals who are transitioning, have transitioned, or are perceived to be transitioning to the gender with which they identify), religion, age, national origin or ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws. -If you are unable to submit your application due to a disability, please contact us at -recruiting@kariusdx.com -and we will accommodate qualified individuals with disabilities.

Keywords: Karius, Redwood City , Senior Bioinformatics Scientist, Assay Development Analytics, Other , Redwood City, California