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Scientist I (Reagent Development)

Company: Guardant Health
Location: Redwood City
Posted on: June 14, 2022

Job Description:

Company Description

Guardant Health is a leading precision oncology company focused on helping conquer cancer globally through use of its proprietary blood tests, vast data sets and advanced analytics. The Guardant Health Oncology Platform leverages capabilities to drive commercial adoption, improve patient clinical outcomes and lower healthcare costs across all stages of the cancer care continuum. Guardant Health has launched liquid biopsy-based Guardant360 -, Guardant360 CDx and GuardantOMNI - tests for advanced stage cancer patients. These tests fuel development of its LUNAR program, which aims to address the needs of early stage cancer patients with neoadjuvant and adjuvant treatment selection, cancer survivors with surveillance, asymptomatic individuals eligible for cancer screening and individuals at a higher risk for developing cancer with early detection.

Job Description

To enable Guardant Health to lead the disruption of cancer treatments through non-invasive cancer screening, the Technology Development Team is seeking a highly motivated Scientist to develop, test, and improve existing and new technologies for rare variant studies with next-generation sequencing. At Guardant, we leverage the most advanced technologies and work with leaders in many different fields to create the most impactful and meaningful technologies for cancer management.

As a Scientist supporting product and technology development, you will work with members within the team and interface with multiple teams including process engineering, clinical operations, bioinformatics, quality control and regulatory affairs. You will be hands-on in the lab and be involved in the design, implementation and validation of new technologies related to liquid and/or tissue biopsy sequencing assays for the detection, treatment, and monitoring of all cancer types.

Duties and Responsibilities:

  • Work in a team environment and independently to perform development studies in support of new and existing assays for rare variant detection with next-generation sequencing
  • Collaborate cross-functionally to transfer new technologies into production environments, write supporting documentation including experiment protocols and reports, SOPs, Specifications, and change requests
  • Think creatively and apply knowledge to design experiments and analyze data for NGS applications in oncology diagnostics
  • Design and perform experiments to develop and improve our assay workstreams
  • Be highly committed and deliver results in a fast-paced start-up environment
  • Lead in troubleshooting efforts with our Operations team and capture lessons learned
  • Engage in technologies from early design of products to support after they are transferred
  • Present data, proposals, and progress in various forums to technical and non-technical audiences
  • Ensure all work is performed and documented in compliance with applicable regulatory and quality practices (FDA, ISO13485)

    • Strong foundation in molecular biology techniques and NGS assay development, exemplified by publications, patent applications, or previous product development experience
    • Comprehensive knowledge of nucleic acid sample isolation, preparation, and NGS sequencing technologies
    • Data analysis skills with experience in bioinformatics and in handling large datasets
    • Consummate team player: ability to contribute to an environment where numerous contributions are required to accomplish complex goals.
    • Enjoy working independently and collaboratively in a fast-paced environment and able to adapt to change
    • Highly motivated responsible self-starter and independent problem solver
    • Self-driven and curious
    • Experience with liquid handling platforms is a plus
    • Sense of humor is a must

      • BA/BS with 8+ years of industry experience; MA/MS with 6+ years of industry experience, PhD with 0-3 years of post-PhD experience in Molecular Biology, Genetics, Biochemistry, or related field
      • 2+ years of related industry work experience preferred

        Additional Information

        Covid Vaccination Policy: Starting January 7, 2022, Guardant Health will require all employees to be fully vaccinated to either (a) establish that they have been fully vaccinated against COVID-19; or (b) request and obtain an approved exemption from Guardant's COVID-19 U.S. Vaccination Policy as a reasonable accommodation, as consistent with applicable laws. An employee is considered fully vaccinated against COVID-19 two weeks after receiving the second dose of a two-dose vaccine or one dose of a single-dose vaccination. Acceptable vaccines are approved or under emergency use authorization by the U.S. Food and Drug Administration (FDA) and/or the World Health Organization (WHO). In addition, fully-vaccinated employees will be required to maintain their fully-vaccinated status under this policy by obtaining, if applicable, any FDA-approved boosters.

        Employee may be required to lift routine office supplies and use office equipment. Majority of the work is performed in a desk/office environment; however, there may be exposure to high noise levels, fumes, and biohazard material in the laboratory environment. Ability to sit for extended periods of time.

        Guardant Health is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

        All your information will be kept confidential according to EEO guidelines.

        To learn more about the information collected when you apply for a position at Guardant Health, Inc. and how it is used, please review our Privacy Notice for Job Applicants.

        Please visit our career page at:


Keywords: Guardant Health, Redwood City , Scientist I (Reagent Development), Other , Redwood City, California

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