Sr. Research Associate, Engineered Stem Cells

Company: Jasper Therapeutics
Location: Redwood City
Posted on: June 16, 2022

Job Description:

Company DescriptionJasper Therapeutics is a clinical-stage company developing therapies for hematopoietic diseases including Leukemias, Sickle Cell Disease, and others. Our first program centers on JSP-191, a highly specific monoclonal antibody to clear diseased hematopoietic stem cells prior to transplantation while avoiding the toxicity associated with chemo-radiation. Our second program centers on genetically engineering hematopoietic stem cells to replace a patient's diseased stem cells. About the Role Jasper is seeking a talented and motivated Senior Research Associate/Associate Scientist, Engineered Stem Cells. This role will be an integral part of the R&D team, contributing to the development of cell and gene therapies in a rapidly growing and well-funded company. This role will report to the Director of Nucleic Acid and Cell Engineering. This position's focus will be to develop technologies around genetic modification of stem cells (mRNA, CRISPR, LNPs, etc.). The exact title and responsibilities will depend on the candidate's experience. Key Responsibilities

• Assist with preclinical research studies focused on engineering stem cells, and spanning molecular biology and cell biology
• Develop and perform in vitro cell-based assays (cell culture, gene editing, flow cytometry, high content imaging, cytokine profiling, cytotoxicity, proliferation, etc.) to characterize cell functional activity.
• Collaboratively develop novel gene editing modalities (mRNA, CRISPR, electroporation, LNPs, screens)
• Build gene expression cassettes (access DNA sequence depositories and databases, read literature, analyze DNA sequences)
• Perform molecular cloning experiments (PCR, capillary electrophoresis, Gibson assembly, bacterial transformation, screening, plasmid preparation, sequencing, etc.)
• Collaborate with partners in Process Development, Regulatory, and Clinical groups to fulfill company objectives (Tech Transfer, IND filings, IP)
• Present internally and in cross-functional meetings Qualifications
  • BS and 2+ years experience
  • Experience with mammalian cell culture required
  • Experience with multi-color flow cytometry, panel design, primary cell culture, cell sorting and/or data analysis is preferred
  • Experience with gene editing via mRNA and/or CRISPR genetic modification is a plus
  • Experience in hematopoietic stem cell and primary immune cell culture is a plus
  • Experience with molecular cloning is a plus
  • Experience in bone marrow and/or stem cell transplant using rodent model is a plus
  • Ability to work well in a highly collaborative team environment, coordinate tasks across multiple projects to meet deadlines, and be accountable
  • Entrepreneurial and comfortable learning new skills and knowledge, and working on new projects as they arise What We Offer
    • High-science environment in a growing company with transformational science to cure devastating diseases
    • Experienced, top-tier team invested in your long-term professional development
    • Collaborative company culture with potential for broad exposure to the entire company
    • Well-funded company with premier investors and public funding
    • Validating collaborations with leading research centers and innovative gene therapy partnerships
    • Competitive compensation and benefits
    • Jasper Therapeutics is an equal opportunity employer
      information will be kept confidential according to EEO guidelines.

Keywords: Jasper Therapeutics, Redwood City , Sr. Research Associate, Engineered Stem Cells, Other , Redwood City, California