Sr. Research Associate, Engineered Stem Cells
Company: Jasper Therapeutics
Location: Redwood City
Posted on: June 16, 2022
Job Description:
Company DescriptionJasper Therapeutics is a clinical-stage
company developing therapies for hematopoietic diseases including
Leukemias, Sickle Cell Disease, and others. Our first program
centers on JSP-191, a highly specific monoclonal antibody to clear
diseased hematopoietic stem cells prior to transplantation while
avoiding the toxicity associated with chemo-radiation. Our second
program centers on genetically engineering hematopoietic stem cells
to replace a patient's diseased stem cells. About the Role Jasper
is seeking a talented and motivated Senior Research
Associate/Associate Scientist, Engineered Stem Cells. This role
will be an integral part of the R&D team, contributing to the
development of cell and gene therapies in a rapidly growing and
well-funded company. This role will report to the Director of
Nucleic Acid and Cell Engineering. This position's focus will be to
develop technologies around genetic modification of stem cells
(mRNA, CRISPR, LNPs, etc.). The exact title and responsibilities
will depend on the candidate's experience. Key Responsibilities
- Assist with preclinical research studies focused on engineering
stem cells, and spanning molecular biology and cell biology
- Develop and perform in vitro cell-based assays (cell culture,
gene editing, flow cytometry, high content imaging, cytokine
profiling, cytotoxicity, proliferation, etc.) to characterize cell
functional activity.
- Collaboratively develop novel gene editing modalities (mRNA,
CRISPR, electroporation, LNPs, screens)
- Build gene expression cassettes (access DNA sequence
depositories and databases, read literature, analyze DNA
sequences)
- Perform molecular cloning experiments (PCR, capillary
electrophoresis, Gibson assembly, bacterial transformation,
screening, plasmid preparation, sequencing, etc.)
- Collaborate with partners in Process Development, Regulatory,
and Clinical groups to fulfill company objectives (Tech Transfer,
IND filings, IP)
- Present internally and in cross-functional meetings
Qualifications
- BS and 2+ years experience
- Experience with mammalian cell culture required
- Experience with multi-color flow cytometry, panel design,
primary cell culture, cell sorting and/or data analysis is
preferred
- Experience with gene editing via mRNA and/or CRISPR genetic
modification is a plus
- Experience in hematopoietic stem cell and primary immune cell
culture is a plus
- Experience with molecular cloning is a plus
- Experience in bone marrow and/or stem cell transplant using
rodent model is a plus
- Ability to work well in a highly collaborative team
environment, coordinate tasks across multiple projects to meet
deadlines, and be accountable
- Entrepreneurial and comfortable learning new skills and
knowledge, and working on new projects as they arise What We Offer
- High-science environment in a growing company with
transformational science to cure devastating diseases
- Experienced, top-tier team invested in your long-term
professional development
- Collaborative company culture with potential for broad exposure
to the entire company
- Well-funded company with premier investors and public
funding
- Validating collaborations with leading research centers and
innovative gene therapy partnerships
- Competitive compensation and benefits
- Jasper Therapeutics is an equal opportunity employer
information will be kept confidential according to EEO
guidelines.
Keywords: Jasper Therapeutics, Redwood City , Sr. Research Associate, Engineered Stem Cells, Other , Redwood City, California
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