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Senior Scientist

Company: Guardant Health
Location: Redwood City
Posted on: June 19, 2022

Job Description:

Company DescriptionGuardant Health is a leading precision oncology company focused on helping conquer cancer globally through use of its proprietary blood tests, vast data sets and advanced analytics. The Guardant Health Oncology Platform leverages capabilities to drive commercial adoption, improve patient clinical outcomes and lower healthcare costs across all stages of the cancer care continuum. Guardant Health has launched liquid biopsy-based Guardant360 -, Guardant360 CDx and GuardantOMNI - tests for advanced stage cancer patients. These tests fuel development of its LUNAR program, which aims to address the needs of early stage cancer patients with neoadjuvant and adjuvant treatment selection, cancer survivors with surveillance, asymptomatic individuals eligible for cancer screening and individuals at a higher risk for developing cancer with early detection.Job DescriptionTo enable Guardant Health to lead the disruption of cancer treatments through non-invasive cancer screening, the Technology Development Team is seeking a highly motivated Senior Scientist to lead the execution of R&D activities for our rare variant detection assays with next-generation sequencing. At Guardant, we leverage the most advanced technologies and work with leaders in many different fields to create the most impactful and meaningful technologies for cancer management.As a Senior Scientist in the Technology Development department, you will interface with engineering, clinical operations, bioinformatics, manufacturing, quality, and regulatory teams. You will perform analysis on high-throughput NGS data and present insights to all management levels. You will design experiments for feasibility, qualification, and validation of new technologies to improve liquid biopsy sequencing assays for the early detection, treatment, and monitoring of all cancer types. This role is expected to include approximately 25% wet lab and 75% dry lab or desk duties.Duties and Responsibilities:

  • Develop, test and validate technologies for rare variant detection with next-generation sequencing
  • Identify areas for improvement in automated high-throughput liquid biopsy assays; propose, test, and implement solutions
  • Write and execute feasibility, development, and validation study plans and reports
  • Write and update SOPs
  • Collaborate cross-functionally with operations, process engineering, and bioinformatics to facilitate effective delivery of sustaining and support activities
  • Lead in troubleshooting efforts with the CLIA labs and Operations teams and captured lessons learned
  • Conceptualize and perform feasibility studies on new assay improvements
  • Ensure all work is performed and documented in compliance with applicable regulatory and quality practices (FDA, ISO13485)
  • Mentor junior team members
  • Present data, proposals, and progress to technical and non-technical audiences QualificationsRequired Skills:
    • Ph.D. degree with a minimim of 4 years of experience or M.S. degree with a minimum of 6 years of experience in Molecular Biology, Genetics, Biochemistry or related field + 8 years of industry experience in genomics or molecular biology developing genomic assays or equivalent experience.
    • 5-8 years of experience in genomics or molecular biology
    • Strong experience in molecular biology techniques and NGS assay development, exemplified by publications, patent applications, and previous product development experience
    • Strong data analysis skills, preferably with experience with JMP, Python, or R handling large datasets
    • Demonstrated ability to organize, document and communicate scientific data
    • Enjoy working independently and collaboratively in a fast-paced environment and able to adapt to change
    • Highly motivated, responsible self-starter and independent problem solver
    • Curiosity and drive Preferred Skills:
      • 3+ years of industry work experience in IVD development or product sustainment
      • Experience with FDA-regulated products and working under design control
      • Experience with assay development for automated liquid handling platforms Additional InformationCovid Vaccination Policy: Starting January 7, 2022, Guardant Health will require all employees to be fully vaccinated to either (a) establish that they have been fully vaccinated against COVID-19; or (b) request and obtain an approved exemption from Guardant's COVID-19 U.S. Vaccination Policy as a reasonable accommodation, as consistent with applicable laws. An employee is considered fully vaccinated against COVID-19 two weeks after receiving the second dose of a two-dose vaccine or one dose of a single-dose vaccination. Acceptable vaccines are approved or under emergency use authorization by the U.S. Food and Drug Administration (FDA) and/or the World Health Organization (WHO). In addition, fully-vaccinated employees will be required to maintain their fully-vaccinated status under this policy by obtaining, if applicable, any FDA-approved boosters.Employee may be required to lift routine office supplies and use office equipment. Majority of the work is performed in a desk/office environment; however, there may be exposure to high noise levels, fumes, and biohazard material in the laboratory environment. Ability to sit for extended periods of time.Guardant Health is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.All your information will be kept confidential according to EEO guidelines.To learn more about the information collected when you apply for a position at Guardant Health, Inc. and how it is used, please review our Privacy Notice for Job Applicants.Please visit our career page at: http://www.guardanthealth.com/jobs/

Keywords: Guardant Health, Redwood City , Senior Scientist, Other , Redwood City, California

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