Molecular Imaging Scientist (PET-CT)

Company: Earli Inc.
Location: Redwood City
Posted on: January 17, 2023

Job Description:

About Earli
The mission of the Biotechnology startup Earli Inc. is large and ambitious: to detect and then cure cancer at its earliest stages, effortlessly and pain free. In other words, 'make cancer a benign experience'. The technology which grounds the company's efforts ushers in a new era in "synthetic biomarkers" as a novel methodology to detect cancer and then subsequently localize and then treat the cancer. The enabling technology utilizes "synthetic biomarkers" as a novel methodology to detect, localize and ultimately destroy cancer. Founded by Sam Gambhir, Cyriac Roeding and David Suhy, the company is well funded by world-class entrepreneurs and venture capital firms. Earli, Inc. is currently based in Redwood City, California.
Who You Are

• You share our same sense of dedication, scientific passion and entrepreneurial spirit
• You work well in a fast-paced and extremely focused startup environment
• You are not only smart, but clever and constantly think outside the box
• You are able to make logical decisions in an instant when there is little time to evaluate
• You are a natural communicator and relationship builder
• You stay calm under high pressure and stress
• You have the ability to multi-task in a serious way, with an extreme attention to detail
• You become a representative of the core DNA of the company through who you are
  Your Primary Responsibilities
  Earli's platform technology uses cancer-activated gene expression to usurp the dysregulated pathways that lead to malignancy for the expression of synthetic biomarker proteins. In this position, you will be leveraging this unique platform for the cancer-activated expression of PET reporter genes and synthetic antigens for the purpose of developing imaging agents and theragnostic approaches. Within this context, you will:
  
  • Assist in the development of improved molecular imaging techniques using expressed PET reporter genes in pre-clinical cancer models and characterizing the outcomes of the experiments with a view towards human clinical translation.
  • Apply expertise and experimental skills in designing antibody-based PET imaging studies (immunoPET) for solid tumors in small and large animals
  • Design and execute in vitro and in vivo experiments to build data package (specificity, sensitivity, PK/PD, toxicity, etc.) around affinity-based imaging agents, both radioactive as non-radioactive.
  • Participate in a team leading the development efforts of the immunoPET agent, including antibody manufacturing, chemistry, and radiolabeling
  • Develop innovative ideas for novel PET reporter genes and antibody-based tracers.
  • Prepare high quality analytic documentation, such as project reports and manuscripts to support publications and regulatory filings.
    Your Required Experience, Knowledge And Skills
    
    • S. or Ph.D. degree in Biophysics, Medical Physics, Bioengineering, Biology, Biochemistry, or a related degree.
    • At least 2+ years of experience working in a post-graduate setting in academic or industry labs, with a proven track record of expertise with medical imaging (PET, CT, SPECT, MRI, etc.) and image segmentation. Experience with working in industry is a plus.
    • Technical background in planning, designing and executing pre-clinical in vitro and in vivo (required) immunoPET experiments in order to evaluate target biology and characterize the efficacy and safety of development candidates in relevant oncology models.
    • Deep knowledge of immunoPET and affinity-based tracer technologies is highly desired
    • A background in synthetic biology and/or the use of PET reporter genes is highly desiredl.
    • Expertise in physical dosimetry and mathematical dose calculations of a wide variety of tracers, specifically antibody-based tracers, is highly desired.
    • Previous experience with QC and interpretation of data from PET imaging analyses tools such as PMOD, MIM, APPIAN or VIVOQUANT platforms would be helpful.
    • Be a go-getter, hands-on kind of person.
    • Keen eye for detail, both with experiments and documentation.
    • Excellent communication skills and ability to work with a diverse interdisciplinary team.
      Why You Should Apply
      
      • Outstanding opportunity to work with some of the top business and scientific minds in the Bay area;
      • Competitive compensation package;
      • Rare opportunity to make a significant impact in the growth and development of a well-funded and scientifically sound start-up.
        If interested in applying, please attach a CV or have a well-developed LinkedIn profile for us to be able to assess your background.
        We look forward to hearing from you!

Keywords: Earli Inc., Redwood City , Molecular Imaging Scientist (PET-CT), Other , Redwood City, California