Principal Scientist, Chemistry
Company: Bolt Biotherapeutics
Location: Redwood City
Posted on: January 18, 2023
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Job Description:
Who We AreBolt Biotherapeutics, based in the San Francisco Bay
Area, is a clinical-stage biotechnology company developing Boltbody
Immune-stimulating Antibody Conjugates (ISACs), a new class of
immuno-oncology therapeutics. This is a unique opportunity to join
and build, with like-minded colleagues, a company that will
transform the lives of individuals with cancers.The PositionBolt
Biotherapeutics, located in Redwood City, CA, is a clinical-stage
biotechnology company developing Boltbody Immune-stimulating
Antibody Conjugates (ISACs), a new class of immuno-oncology
therapeutics that have eliminated tumors following systemic
administration in preclinical studies while also developing
immunological memory, which may lead to more durable clinical
responses for patients. This is a unique opportunity to join and
build, with likeminded colleagues, a company that will transform
the lives of individuals with cancers.Key Responsibilities---
Design, synthesis, purification, and characterization of novel
immune agonists payloads for ISAC platform--- Closely follow
emerging results from SAR, pharmacological and ADME assays to
contribute to the advancement of lead linker-payloads---
Troubleshoot and optimize synthetic routes--- Collaborate with
chemists, biologists, and pharmacologists to interpret in vitro and
in vivo--- Contribute to the writing of technical documents,
patents, scientific manuscripts, etc.--- Design, synthesis,
purification, and characterization of novel linkers to improve
biophysical properties of conjugates--- Understand published
scientific and patent literature outside of their immediate area of
expertise and apply this understanding to drive
innovationQualifications--- Ph.D. in Chemistry or closely related
field and a minimum of 8 years of industry experience--- Aptitude
for presentations at different levels, from project teams to senior
leadership--- Mentorship, development, and supervision of junior
staff--- Possesses strong medicinal chemistry bench skills and
experience designing and executing multi-step syntheses--- Hands on
experience utilizing knowledge of organic chemistry reaction
mechanisms, reactivity, and primary principles to troubleshoot and
optimize synthetic routes--- Strong track record of utilizing SBDD
and/or ligand-based drug design to generate lead molecules---
Ability to follow SAR and pharmacological data to design new
molecules and advance leads--- Practiced in chromatographic
purification techniques and modern analytical techniques---
Experience with antibody-drug conjugates (ADCs) or targeted drug
delivery preferred, Immune agonists a plus--- Chemistry Team Lead
on project a plus--- Requires working in a laboratory environment
with hazardous chemicals. Protective clothing, gloves, and safety
glasses are required while working in the lab--- Ability to lift
containers or instruments (up to 25 pounds) and work standing at a
fume hood or lab bench for extended periods We are an Equal
Opportunity Employer offering a competitive salary and benefits
package. Applicants should be legally entitled to work for any
employer in the US. Bolt Biotherapeutics requires all U.S. new
hires to be fully vaccinated for COVID-19 prior to the first date
of employment. As required by applicable law, Bolt will consider
requests for Reasonable Accommodations. Note to Employment
Agencies: Please do not forward any agency resumes. The company
will not be responsible for any fees related to resumes that are
unsolicited.
Keywords: Bolt Biotherapeutics, Redwood City , Principal Scientist, Chemistry, Other , Redwood City, California
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