Senior Principal Scientist Machine Learning / Protein Design Prediction
Company: Bristol Myers Squibb Company
Location: Redwood City
Posted on: January 25, 2023
Job Description:
Working with UsChallenging. Meaningful. Life-changing. Those
aren't words that are usually associated with a job. But working at
Bristol Myers Squibb is anything but usual. Here, uniquely
interesting work happens every day, in every department. From
optimizing a production line to the latest breakthroughs in cell
therapy, this is work that transforms the lives of patients, and
the careers of those who do it. You'll get the chance to grow and
thrive through opportunities uncommon in scale and scope, alongside
high-achieving teams rich in diversity. Take your career farther
than you thought possible.Bristol Myers Squibb recognizes the
importance of balance and flexibility in our work environment. We
offer a wide variety of competitive benefits, services and programs
that provide our employees with the resources to pursue their
goals, both at work and in their personal lives. Read more: Job
DescriptionWe are seeking a collaborative machine learning
scientist with expertise in protein structure prediction and design
to join the Predictive Sciences team. You will be responsible for
the research and development of innovative computational approaches
and workflows to design and optimize proteins. This role provides
the opportunity to leverage large-scale proprietary datasets and
work with subject matter experts on cross-functional teams to solve
challenging problems in how we discover and engineer the next
generation of biotherapeutics.Responsibilities
- Pioneer machine learning research into antibody-antigen
interaction modeling and design using internal and external
datasets.
- Partner with project teams to advance sequence- and
structure-based antibody discovery and design.
- Develop and implement computational approaches and prediction
algorithms that can map linear and three-dimensional epitopes,
optimize binding scaffolds and library design to guide screening,
identify and mature the affinity of antibody hits, and assess
potential liabilities and optimal development options.
- Communicate findings and recommend follow-up actions in
multiple settings such as 1:1, seminars, group, and project
meetings.Basic Qualifications
- Bachelor's Degree in structural bioinformatics, computer
science, engineering, statistics, or similar and 10+ years of
academic / industry experience
- OR Master's Degree in structural bioinformatics, computer
science, engineering, statistics, or similar and 8+ years of
academic / industry experience
- Ph.D. in structural bioinformatics, computer science,
engineering, statistics, or similar with 8+ years of relevant
experience.Preferred Qualifications
- Ph.D. in structural bioinformatics, computer science,
engineering, statistics, or similar with 8+ years of relevant
experience.
- Deep expertise in modern neural network architectures including
transformers, autoencoders, GANs, attention models. Familiarity
with Tensorflow/JAX and its ecosystem, as well as other platforms
such as scikit, and design of effective experiments and
metrics.
- Experience with state-of-the-art machine learning approaches
applied to biological sequence data (RNA, DNA, proteins) in the
molecular and cell biology domains.
- Proven track record of contributing to and helping advance
multi-disciplinary team projects.
- Expertise with a high-level programming language such as R or
Python for sophisticated data analysis and reproducible research
practices.
- Scientific curiosity with an ability to identify questions
machine learning approaches can address, and the skills to develop
solutions both independently and collaboratively.
- Excellent problem-solving skills and teamwork.
- Strong communication, data presentation, and visualization
skills.
- Knowledge in biochemistry or protein engineering is a plus.The
starting compensation for this jobis a range from
$159,000-$185,000, plus incentive cash and stock opportunities
(based on eligibility).The starting pay rate takes into account
characteristics of the job, such as required skills and the where
the job is performed.Final individual compensation will be
decidedbased on demonstratedexperience.For more on benefits, please
visit our . Eligibility for specific benefits listed on our BMS
Careers site may vary based on the job and location. If you come
across a role that intrigues you but doesn't perfectly line up with
your resume, we encourage you to apply anyway. You could be one
step away from work that will transform your life and career.
Uniquely Interesting Work, Life-changing CareersWith a single
vision as inspiring as "Transforming patients' lives through
science ", every BMS employee plays an integral role in work that
goes far beyond ordinary. Each of us is empowered to apply our
individual talents and unique perspectives in an inclusive culture,
promoting diversity in clinical trials, while our shared values of
passion, innovation, urgency, accountability, inclusion and
integrity bring out the highest potential of each of our
colleagues.On-site ProtocolPhysical presence at the BMS worksite or
physical presence in the field is a necessary job function of this
role, which the Company deems critical to collaboration,
innovation, productivity, employee well-being and engagement, and
it enhances the Company culture.COVID-19 InformationTo protect the
safety of our workforce, customers, patients and communities, the
policy of the Company requires all employees and workers in the
U.S. and Puerto Rico to be fully vaccinated against COVID-19,
unless they have received an exception based on an approved request
for a medical or religious reasonable accommodation.Therefore, all
BMS applicants seeking a role located in the U.S. and Puerto Rico
must confirm that they have already received or are willing to
receive the full COVID-19 vaccination by their start date as a
qualification of the role and condition of employment.This
requirement is subject to state and local law restrictions and may
not be applicable to employees working in certain jurisdictions
such as Montana. This requirement is also subject to discussions
with collective bargaining representatives in the U.S.BMS is
dedicated to ensuring that people with disabilities can perform
complex functions through a transparent recruitment process,
reasonable workplace adjustments and ongoing support in their
roles. Applicants can request an accommodation prior to accepting a
job offer. If you require reasonable accommodation in completing
this application, or in any part of the recruitment process, direct
your inquiries to . Visit eeo -accessibility to access our complete
Equal Employment Opportunity statement.BMS will consider for
employment qualified applicants with arrest and conviction records,
pursuant to applicable laws in your area.Any data processed in
connection with role applications will be treated in accordance
with applicable data privacy policies and regulations.
Keywords: Bristol Myers Squibb Company, Redwood City , Senior Principal Scientist Machine Learning / Protein Design Prediction, Other , Redwood City, California
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