Senior Scientist, Flow Cytometry Translational Research

Company: Bristol-Myers Squibb
Location: Redwood City
Posted on: May 23, 2023

Job Description:

Working with UsChallenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: When you join BMS, you are joining a diverse, high-achieving team united by a common mission.The Tumor Microenvironment Thematic Research Center (TME TRC) is focused on developing therapeutic targets at the intersection of tumor, stromal and immune biology within the TME with the goal of enhancing responsiveness to checkpoint blockade and targeted therapies and transforming response and durability rates for cancer patients. Comprising of scientists across multiple disciplines we are responsible for the biology and translational science necessary to support drug development from target identification through to first in human studies.Position Summary:We are seeking a highly motivated, agile, and experienced candidate to join Flow Cytometry group within the Translational Research team at the Tumor Microenvironment Thematic Research Center (TME TRC) in Redwood City, CA. Our group is responsible for developing and validating all flow cytometry-based complex multi-parameter biomarker assays from program inception to First in Human studies, in alignment with clinical development objectives, as well as clinic-ready target engagement and pharmacodynamic biomarker assays for TME TRC programs. The deep immunophenotyping data generated from this group will influence a broad array of decisions around dose optimization, indication prioritization, and potential drug combinations. This role will require Monday through Friday onsite work at our Redwood City CA location.Position Responsibilities:In the role as a Senior Scientist within the TME TRC Flow Cytometry group, the ideal candidate:

• Has a deep understanding of immunology and cancer biology and serves as a subject matter expert.
• Has a particular passion for all aspects of creating, developing, executing, evaluating, troubleshooting, validating, and implementing high dimensional flow cytometry assays (30+ colors, Cytek Aurora preferred), including deep immunophenotyping of immune cell subsets and receptor occupancy endpoints, to support our translational and pre-clinical efforts in a variety of oncology disease models.
• Be responsible for delivery of robust, high quality data packages, and provides subject matter advice to teams in the selection of antibody panels and panel constituents.
• Ensures all work is conducted in compliance with regulations and follows the appropriate SOPs with organized record keeping.
• Be able to handle multiple projects concurrently and possesses a good balance of creative and analytical skills
• Collaborates with internal scientists and our external business partners (both Academic and CRO) to integrate flow-based biomarker data into an overall understanding of drug MOA and efficacy.
• Serves as a technical and scientific expert on project sub-teams, including contributing ideas, developing plans, execution of the plan, timely reporting of complex scientific data, drawing conclusions, and making recommendations.
• Develops partnership and collaborates with members of research, automation, bioinformatics, process development, high-throughput screening, and clinical flow cytometry groups across sites within the organization to enable novel flow cytometry technology and data analysis breakthroughs.
• Must be able to set and understand priorities in a local and matrixed environment, must be a team player with a collaborative spirit, and capable of building and maintaining networks within and outside the organization.
• As a member of the Flow Cytometry group, serves as the backup for the upkeep of flow cytometry equipment, and contributes to novel scientific tools and capital equipment evaluation for effective and through early-stage research and pre-clinical programs to ensure that technical and scientific standards meet state-of-the-art expectations.Experience = Basic Qualifications:
  • Bachelor's Degree
    • 7+ years of academic and / or industry experienceOr
      • Master's Degree
        • 5+ years of academic and / or industry experienceOr
          • Ph.D. or equivalent advanced degree in the Life Sciences
            • 2+ of academic and / or industry experiencePreferred Qualifications:
              • Ph.D. with 2+ or M.S. with 7+ years of academic and/or industry experience in immunology, cancer biology, biomedical science, or related disciplines, with Immunological knowledge covering phenotyping of multiple subpopulations of cells
              • At least 3 years prior hands-on laboratory experience working with high dimensional flow cytometers (Cytek Aurora preferred, or BD Symphony A5 SE), with design and execution of 16+ color flow cytometry panels
              • Theoretical and hands on experience with commercial flow cytometry software including BD FACS Diva, FlowJo, OMIQ, Cytobank, or FCS Express for high-dimensional data analysis (e.g., tSNE, UMAP, SPADE, CITRUS, FlowSOM)
              • Experience with cell culture techniques and tissue processing, and background in working with immunology or oncology samples including whole blood, PBMC, cell lines and single-cell suspension from tissue samples
              • Experience in the design, development, troubleshooting, validation, and implementation of novel flow cytometry assays to support translational and pre-clinical measurements and their transition to clinical development when applicable
              • Experience with complexities of reporting and presenting high parameter data to clinical flow cytometry colleagues, with understanding of clinical and non-clinical flow cytometry biomarker assay development, validation, and implementation
              • Ability to maintain a disciplined approach, ensuring a relentless focus on quality, compliance, scientific rigor, and operational excellence
              • Experience with laboratory robotics and in improving flow processes
              • Demonstrated judgment and decision making, especially for handling and prioritizing multiple requests and tasks in parallel with internal and external collaborators, and the ability to work to tight deadlines and in high pressure situations
              • Excellent collaboration and interpersonal skills to contribute to biomarker testing strategies and communicate efficiently with colleagues from all phases of clinical drug development, and operate effectively in a highly matrixed environmentThe starting compensation for this job is a range from $109,000.00 -$150,700.00, plus incentive cash and stock opportunities (based on eligibility).The starting pay rate takes into account characteristics of the job, such as required skills and where the job is performed.Final, individual compensation will be decided based on demonstrated experience.Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit our BMS Career Site.Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sicktime off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program.BMSONCRDBMSDDTMRCA#LI-OnsiteIf you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.Uniquely Interesting Work, Life-changing CareersWith a single vision as inspiring as "Transforming patients' lives through science--- ", every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.On-site ProtocolPhysical presence at the BMS worksite or physical presence in the field is a necessary job function of this role, which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and it enhances the Company culture.COVID-19 InformationTo protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation.Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment.This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to . Visit to access our complete Equal Employment Opportunity statement.BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

Keywords: Bristol-Myers Squibb, Redwood City , Senior Scientist, Flow Cytometry Translational Research, Other , Redwood City, California