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Production Scientist

Company: Synthego Corporation
Location: Redwood City
Posted on: January 6, 2022

Job Description:

Synthego is enabling genome engineering at scale with a blend of scientific instrumentation, industrial automation, and data science. Our team of scientists and engineers are putting multidisciplinary fields together to solve problems that no one field can tackle alone. - We are searching for an innovative, experienced scientist to lead the AdvancedRNA production team, support the transfer of new protocols into production, troubleshoot issues in the lab, as well as train and mentor a team of research associates. With a focus on quality and scale, this role will be responsible for developing and executing plans to produce sgRNA to unique customer specifications, document the process by establishing world-class operating protocols, initiate process improvement projects to drive reproducibility and efficiency, and manage a growing team of AdvancedRNA Research Associates. The ideal candidate is well-versed in oligonucleotide synthesis and purification techniques, analytical instrumentation, and GLP/GMP. This position requires the tact to manage and mentor others, as well as the sense of urgency and ability to get hands-on when necessary. What You'll Do

  • Ownership of complex custom orders including equipment and production resource planning as well as the successful on-time delivery of high quality, customer orders
  • End-to-end oligonucleotide synthesis and purification in our ISO clean rooms to fulfill preclinical grade sgRNA orders
  • Development and training of research associates, production specialists and associate scientists
  • Development of assays and quality control protocols for the qualification of raw and in-process materials
  • End to end ownership of complex custom orders, including equipment and production resource planning as well as the successful on-time delivery of high quality, customer orders
  • Collaborate with science, engineering, and marketing teams to design and implement innovative solutions to meet and exceed customer expectations
  • Leading SOP drafting and curation for new product offerings and underlying production processes.
  • Continuous improvement mindset to address challenges related to process inefficiencies, scheduling or cost reduction
  • Operate complex scientific instrumentation for the synthesis and purification of oligonucleotides, with the innate ability to interpret LC/MS data
  • Coordinate with Chemistry Development and Quality Assurance to ensure the seamless transfer of new products and processes into production About You
    • PhD or MS in Chemistry, or relevant industry experience
    • PhD +1 years of experience in a high throughput reagent manufacturing operation, ideally oligonucleotide production or MS + 4 years experience.
    • Previous experience employing analytical methods (including but not limited to)UPLC/HPLC, GC, LC/MS
    • Strong understanding of oligonucleotide synthesis, purification, and analytical laboratory equipment and chemistries
    • Experience with formal quality management systems required, ISO 9001 and cGMP preferred
    • Innovative, motivated, and independent leader with a player/coach mentality
    • Excellent interpersonal skills Company Perks & Benefits
      • 4x Daily shuttle to and from San Francisco (more locations to come)
      • Generous equity at an early stage company
      • Fully stocked kitchen and snacks
      • Catered meals About Us Synthego is a genome engineering company that enables the acceleration of life science research and development in the pursuit of improved human health. The company leverages machine learning, automation, and gene editing to build platforms for science at scale. With its foundations in engineering disciplines, the company's platforms vertically integrate proprietary hardware, software, bioinformatics, chemistries, and molecular biology to advance basic research, target validation, and clinical trials. By providing both commercial and academic researchers and therapeutic developers with unprecedented access to cutting-edge genome engineering, Synthego is at the forefront of innovation, accelerating the development of truly engineered biology.

Keywords: Synthego Corporation, Redwood City , Production Scientist, Professions , Redwood City, California

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